Abstract #4241
Progression of Skeletal Muscle Dysfunction Assessed by 31P MRS and BOLD MRI in Non-obese Type 2 Diabetic Rats
Yuchi Liu 1 , Xunbai Mei 1 , Andrew Slabic 1 , Nicola Lai 1 , and Xin Yu 1,2
1
Biomedical Engineering, Case Western Reserve
University, Cleveland, Ohio, United States,
2
Radiology,
Case Western Reserve University, Cleveland, Ohio, United
States
This study investigated changes in mitochondrial
response to ischemia in skeletal muscle of non-obese
type 2 diabetic rats. Mitochondrial function and tissue
oxygenation was evaluated in vivo using interleaved 31P
Magnetic Resonance Spectroscopy (MRS) and Blood Oxygen
Level-Dependent (BOLD) imaging. Results from 12- and
18-week rats showed a progression of mitochondrial
dysfunction.
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