Abstract #4233
Reproducibility of carnosine quantification in the calf muscle by 1H MRS at 7T and detection of its concentration changes following acute physical activity
Ivica Just Kukurova 1 , Barbara Ukropcov 2,3 , Marjeta Tuek Jelenc 1 , Milan Sedliak 4 , Marek Chmelik 1 , Jozef Ukropec 2 , Martin Krk 1,5 , Siegfried Trattnig 1 , and Ladislav Valkovič 1,6
1
High Field MR Centre, Department of
Biomedical Imaging and Image-guided Therapy, Medical
University of Vienna, Vienna, Austria,
2
Institute
of Experimental Endocrinology, Slovak Academy of
Sciences, Bratislava, Slovakia,
3
Faculty
of Medicine, Comenius University, Bratislava, Slovakia,
4
Faculty
of Physical Education and Sport, Comenius University,
Bratislava, Slovakia,
5
Department
of Internal Medicine III, Medical University of Vienna,
Vienna, Austria,
6
Institute
of Measurement Science, Slovak Academy of Sciences,
Bratislava, Slovakia
Reproducibility of carnosine measurement in the calf
muscles was tested on 5 volunteers by STEAM sequence
with very good results of CV (6.3% for SOL, 9.1% for
GM). Effect of one hour running on carnosine
concentration was examined on 7 volunteers, which did
not prove to be significant. However, changes in the
shape of the carnosine peak appeared, in form of its
widening or splitting and also its shift. As carnosine
is pH sensitive, we suppose it is a consequence of
different use of carnosine buffering capacity in
oxidative and glycolytic muscle fibres leading to
different pH in these compartments.
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