Abstract #4002
Evaluation of liver fibrosis with Intravoxel incoherent motion MR imaging: an experimental study in rat model
Caiyuan Zhang 1 , Yanfen Cui 1 , Yong Zhang 2 , and Dengbin Wang 1
1
Department of Radiology, Xinhua Hospital,
Shanghai Jiao Tong University School of Medicine,
Shanghai, Shanghai, China,
2
MR
Research, GE healthcare, Shanghai, Shanghai, China
Intravoxel incoherent motion (IVIM) MR imaging derived
parameters, as a non-invasive method could separate the
effect of water molecular diffusion and microcirculation
perfusion and therefore has potential to evaluate the
staging of liver fibrosis. Currently, studies of IVIM in
patient or animal model with liver fibrosis yielded
contradictory results. Therefore, we performed IVIM MR
imaging for well-controlled carbon tetrachloride induced
liver fibrosis model in rats to evaluate its capability
for prediction of severity of liver fibrosis. Based on
histopathological findings, we analyzed the relationship
between normal rats and rats with different staging of
liver fibrosis, and relationship among individual
fibrosis staging. Our studies indicated that D and D*
showed better diagnostic performance than ADC for
predicting the presence of liver fibrosis, particularly,
D* has potential to differentiate moderate and advanced
fibrosis from hepatic fibrosis. It is promising that
parameters derived from IVIM were stable and has
potential to be clinical use in monitoring fibrosis
progression and evaluation of anti-fibrosis treatment
response.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
