Abstract #3965
Functional connectivity assessment using R2* resting-state functional MRI
Venkata Veerendra Nadh Chebrolu 1 , Suresh Joel 1 , Brice Fernandez 2 , Ek Tsoon Tan 3 , Luca Marinelli 3 , Dattesh Shanbhag 1 , Radhika Madhavan 1 , Rachel Connett 4 , Ajit Shankaranarayanan 4 , and John Schenck 5
1
Medical Image Analysis Lab, GE Global
Research, Bangalore, Karnataka, India,
2
GE
Healthcare, Muenchen, Germany,
3
MRI
Laboratory, GE Global Research, NY, United States,
4
GE
Healthcare, CA, United States,
5
MRI
Technologies & Systems, GE Global Research, NY, United
States
In recent years, resting state functional connectivity
(rs-FC) has been widely used to image brain function.
rs-FC is measured by correlation of blood oxygen level
dependent (BOLD) MRI signal time-courses. BOLD signal
has contributions from cerebral blood flow (CBF),
cerebral blood volume (CBV) and cerebral metabolic
oxygen rate (CMRO2). The initial magnetization (M) is
associated with CBF and CBV. Transverse relaxation rate
(R2*) is associated with CMRO2, which is related more
specifically with neuronal activity than CBF and CBV. In
this work, we estimate functional connectivity using R2*
time-courses and compare the results with conventional
BOLD rs-fMRI.
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