Abstract #3963
An exploration of task based fMRI in neonates using echo-shifting to allow acquisition at longer TE without loss of temporal efficiency
Giulio Ferrazzi 1 , Rita G. Nunes 1,2 , Tomoki Arichi 1 , Maryam Abaei 1 , Emer Hughes 1 , Anthony Price 1 , and Joseph Hajnal 1,3
1
Centre for the Developing Brain, King's
College London, London, United Kingdom,
2
Instituto
de Biofisica e Engenharia Biomedica, Universidade de
Lisboa, Lisbon, Portugal,
3
Division
of Imaging and Sciences and Biomedical Engineering,
King's College London, London, United Kingdom
There is growing interest in fMRI of neonates. However,
T2* is longer in immature brains, suggesting that
optimal fMRI requires different parameter settings. We
explore the use of echo-shifted EPI to detect task
activation in a motor paradigm in neonates using longer
echo-times to enhance sensitivity to the BOLD effect,
first testing for a suitable echo time and then running
dual echo and echo shifted sequences on a small group of
infants. The pilot data obtained confirmed that longer
echo times improve detection of motor activation and
that signal recovery combined with increased efficiency
can be achieved with echo-shifting.
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