Abstract #3962
Investigation of local brain activity changes in restless legs syndrome using regional homogeneity: a preliminary study
Yong Zhang 1 , Kang-An Li 2 , Yun-Cheng Wu 2 , Qian Jiang 1 , Zhenyu Zhou 3 , and Gui-Xiang Zhang 2
1
GE Healthcare China, Shanghai, Shanghai,
China,
2
Shanghai
First Peoples Hospital, Shanghai, Shanghai, China,
3
GE
Healthcare China, Beijing, Beijing, China
This preliminary study used regional homogeneity (ReHo),
a novel resting-state fMRI parameter to investigate
local brain activity changes in restless legs syndrome
(RLS), a common neurological disorder characterized by
an urge to move the legs and paraesthesias deep in the
legs. Ten RLS patients and ten age- and gender-matched
healthy controls were recruited for comparison. The RLS
group showed increased ReHo regions in bilateral middle
frontal gyrus, anterior cingulate cortex, caudate
nucleus, insula, left putamen and thalamus as compared
to normal controls, which might provide interesting
insight into the mechanism of the disease.
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