Abstract #3951
The impact of white matter hyperintensities on brain functional connectivity in amnestic mild cognitive impairment patients.
Mario Torso 1 , Chiara Mastropasqua 1 , Giovanni Giulietti 1 , Laura Serra 1 , Giusy Olivito 2,3 , Elisa Tuzzi 1 , Barbara Span 1 , Carlo Caltagirone 4,5 , Mara Cercignani 6 , and Marco Bozzali 1
1
Neuroimaging Laboratory, Santa Lucia
Foundation, IRCCS, Rome, Italy,
2
Ataxia
research Laboratory, Santa Lucia Foundation, IRCCS,
Rome, Italy,
3
Department
of psychology, University of Rome Sapienza, Rome, Italy,
4
Department
of Clinical and Behavioural Neurology, Santa Lucia
Foundation, IRCCS, Rome, Italy,
5
Department of
Neuroscience, University of Rome Tor Vergata, Rome,
Italy,
6
CISC,
Brighton & Sussex Medical School, Brighton, Sussex,
United Kingdom
In this study we used resting state f-MRI to investigate
the contribution of White Matter Hyperintensities (WMHs)
in determining functional connectivity (FC) changes in
amnestic Mild Cognitive Impairment patients, the
prodromal stage of Alzheimer disease. WMHs volumes were
quantified by semiautomatic method on TSE images and
used to distinguish patients in two different groups
(high WMHs volume H and low WMHs volume L). The main
finding of the study was that a higher WMHs volume can
determine changes in FC and that these alterations are
associated with the presence of cognitive deficits in
the patients.
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