Abstract #3865
DCE-MRI Assessment of Soft-Tissue Sarcoma Response to Preoperative Therapy
Wei Huang 1 , Megan L Holtorf 1 , Aneela Afzal 1 , Yiyi Chen 1 , Brooke R Beckett 1 , and Christopher W Ryan 1
1
Oregon Health & Science University,
Portland, OR, United States
Twenty patients with extremity soft-tissue sarcoma who
underwent preoperative chemoradiotherapy consented to
research DCE-MRI, performed before, after one cycle of
chemotherapy, and after completion of therapy before
surgery. Ktrans and kep at baseline, after one cycle of
therapy, and percent change were much better than RECIST
tumor size measurement for early prediction of therapy
response. Post-therapy Ktrans, ve, and kep were
negatively correlated with necrosis percentage (NP) of
the surgical specimen. No significant relationship was
observed between post-therapy RECIST and NP.
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