Abstract #3861
Immunocytokine facilitation of natural killer cells accumulation in tumors
Naomi S. Sta Maria 1 , Samuel R. Barnes 1 , David Colcher 2 , Andrew A. Raubitschek 2 , and Russell E. Jacobs 1
1
Biology and Biological Engineering,
California Institute of Technology, Pasadena, CA, United
States,
2
Cancer
Immunotherapeutics & Tumor Immunology, City of Hope,
Duarte, CA, United States
We investigated whether the priming of tumors with
immunocytokines can potentiate the accumulation of
adoptive human natural killer cells labeled with
ferumoxytol, an FDA-approved USPIO, in tumors. We used
T2* weighted multi-gradient echo to generate parametric
R2* maps of the tumors in NOD-scid-gamma-null mice with
human colorectal adenocarcinoma cells, LS-174T.luc. Mice
were differentiated into control or immunocytokine
treated groups and were imaged pre and post (5hr and
10hr) injection of NK cells. Pretreated mice showed
significant increases in tumor R2* values at the 10hr
time point. MRI can be used to assess efficacy of
adoptive NK cell transfer.
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