Abstract #3860
Metabolic Imaging of Early Tumor Therapy
Charles S. Springer 1,2 , Xin Li 3 , Mohan L. Jayatilake 4 , Martin M. Pike 2,3 , William D. Rooney 3 , Rosalie C. Sears 2,5 , and Wei Huang 2,3
1
Advanced Imaging Research Center, Oregon
Health & Science University, Portland, Or, United
States,
2
Knight
Cancer Institute, Oregon Health & Science University,
Portland, Oregon, United States,
3
Advanced
Imaging Research Center, Oregon Health & Science
University, Portland, Oregon, United States,
4
Radiography
and Radiotherapy, University of Peradeniya, Peradeniya,
Peradeniya, Sri Lanka,
5
Molecular
and Medical Genetics, Oregon Health & Science
University, Portland, Oregon, United States
Normally, DCE-MRI estimates vascular parameters, K
trans
and
v
p
. However, shutter-speed analysis allows
determination of cellular, metabolic parameters, k
io
and
v
i
. The k
io
quantity
tracks cell membrane Na
+
,K
+
-ATPase
activity. Exemplified with human and murine breast
cancers, we show that these enable the discrimination of
cytotoxic and targeted therapies in their early actions.
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