Abstract #3838
Intraprostatic Lipid Spectroscopic Imaging of the Prostate Cancer
Xin Li 1 , Jackilen Shannon 1 , Mark G Garzotto 1,2 , Chris Amling 1 , William J Woodward 1 , George Thomas 1 , Elizabeth Dacey 1,2 , Xiaohua Wang 1,2 , Paige Farris 1 , Wesley Stoller 2 , Ann Martinez Acevedo 1 , Amy Palma 1 , Manoj K Sammi 1 , William D Rooney 1 , Fergus V Coakley 1 , and Jonathan Q Purnell 1
1
Oregon Health & Science University,
Portland, Oregon, United States,
2
Portland
VA Medical Center, Portland, Oregon, United States
The lipogenic fatty acid synthase (FAS) is responsible
for de novo fatty acid and triglyceride synthesis in
tissue. Recently, FAS has been characterized as an
oncogene and its overexpression is reported in several
cancers which include that of the prostate. The altered
lipid deposition of cancerous tissue thus can
potentially be an independent biomarker for cancer
aggressiveness monitoring. In this work, MR
spectroscopic imaging (MRSI) is used to quantify
prostatic lipid concentration for prostate cancer.
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