Abstract #3820
Evaluation of metronomic chemotherapy in a mouse model using DCE-MRI and DWI
Melanie Freed 1,2 , Kerryanne Winters 1,2 , Jin Zhang 1,2 , and Sungheon G. Kim 1,2
1
Center for Advanced Imaging Innovation and
Research (CAI2R), Dept. Radiology, NYU School of
Medicine, New York, NY, United States,
2
Bernard
and Irene Schwartz Center for Biomedical Imaging, Dept.
Radiology, NYU School of Medicine, New York, NY, United
States
Metronomic chemotherapy is a promising method that
delivers chemotherapy in low, frequent doses and has
been shown to demonstrate superior response over
traditional chemotherapy in some cases. There is a need
to develop mouse models and techniques for evaluating
dose and scheduling of metronomic chemotherapy to
optimize its usage and benefits. In this study, we
investigate the use of DCE-MRI and DWI to evaluate
metronomic chemotherapy of BALB/c mice with implanted
4T1 mouse mammary tumor cells. Our data suggests this
may be a good model for advanced breast cancer and that
ADC values may be sensitive to early therapy response.
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