Abstract #3819
Source-based nosologic imaging of response to therapy in pre-clinical glioblastoma
Sandra Ortega-Martorell 1,2 , Ivan Olier 3 , Teresa Delgado-Goi 4 , Magdalena Ciezka 2,5 , Ana Paula Candiota 2,5 , Margarida Juli-Sap 2,5 , Mart Pumarola 2,5 , Paulo Lisboa 1 , and Carles Ars 2,5
1
Liverpool John Moores University, Liverpool,
Merseyside, United Kingdom,
2
Networking
Research Center on Bioengineering, Biomaterials and
Nanomedicine, CIBER-BBN, Cerdanyola del Valls, Spain,
3
The
University of Manchester, Manchester, United Kingdom,
4
The
Institute of Cancer Research, London, United Kingdom,
5
Universitat
Autnoma de Barcelona, Cerdanyola del Valls, Spain
A source-based extraction method is shown to produce
nosological images allowing convenient non-invasive
tracking of preclinical GBM response to therapy. The
source-based classifier was developed from a training
set of 14 C57Bl/6 mice harbouring GL261 GBM and
validated in a further independent set of 24 additional
mice using comparison with post-sacrifice
histopathology.
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