Abstract #3616
Compromised cerebrovascular reactivity is reversible in patients with carotid artery stenosis: A BOLD MRI study
Jian Hui-Shan 1,2 , Chang Ting-Yu 1 , Huang Kuo-Lun 1 , Chang Yeu-Jhy 1 , Chang Chien-Hung 1 , Wai Yau-Yau 3 , Yeh Chih-Hua 3 , Lee Tsong-Hai 1 , and Liu Ho-Ling 4,5
1
Department of Neurology and Stroke Center,
Chang Gung Memorial Hospital, Taoyuan, Taiwan,
2
Departiment
of Biomedical Engineering and Environmental Sciences,
Tsing Hua University, Hsinchu, Taiwan,
3
Department
of Medical Imaging and Intervention, Chang Gung Memorial
Hospital, Taoyuan, Taiwan,
4
Department of
Medical Imaging and Radiological Sciences, Chang Gung
University, Taoyuan, Taiwan,
5
Department
of Imaging Physics, The University of Texas M. D.
Anderson Cancer Center, Houston, TX, United States
We investigated whether the impaired cerebrovascular
reactivity dynamics in patients with unilateral ICA
stenosis is reversible after carotid artery stenting (CAS).
Ten subjects underwent dynamic BOLD MRI during repeated
breath-holding, before and after stenting, on a 3T
scanner. Signal time courses from the MCA territory were
extracted for each hemisphere for evaluation. We found
that the ipsilateral MCA time course was significantly
compromised, presenting as smaller amplitude, wider
response and delayed onset, as compared to the
contralateral one before CAS (p<0.05). This phenomenon
was recovered after CAS, demonstrating significantly
improved correlation between BOLD responses obtained
from the two hemispheres (p<0.001).
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