Abstract #3615
Non-invasive identification of crossed cerebellar diaschisis following cerebral ischemic stroke using combined measures of cerebrovascular reactivity, cerebral blood flow, and Wallerian degeneration
Carlos C. Faraco 1 , Manus J. Donahue 1,2 , Cari L. Buckingham 1 , Fei Ye 3 , Lori C. Jordan 2 , Daniel F. Arteaga 1 , and Megan K. Strother 1
1
Radiology and Radiological Sciences,
Vanderbilt University School of Medicine, Nashville, TN,
United States,
2
Department
of Neurology, Vanderbilt University Medical Center,
Nashville, TN, United States,
3
Center
for Quantitative Sciences, Vanderbilt University School
of Medicine, Nashville, TN, United States
Cross cerebellar diaschisis (CCD) is a hypometabolic
condition associated with reduced cerebellar blood flow
to the hemisphere contralateral to a supratentorial
lesion. CCD remains poorly understood partly owing to
use of diagnostic modalities not readily available
and/or not suitable for longitudinal monitoring, e.g.,
PET, SPECT, and Gd-MR. The primary aim of this study was
to determine whether cerebellar BOLD-weighted
cerebrovascular reactivity (CVR) contralateral to
supratentorial infarcts correlated with structural and
clinical measures of CCD. We demonstrate that
BOLD-weighted CVR in the contralateral cerebellar
hemisphere correlates with these measures and is a
viable, non-invasive alternative to traditional CCD
diagnostic imaging modalities.
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