Abstract #3602
The alterations of functional brain network and its relationship to cognitive decline in patients with carotid stenosis: a resting-state fMRI study
Pei-Shan Ho 1,2 , Ting-Yu Chang 3 , Meng-Yang Ho 4 , Chang-Wei Wu 5 , Kuo-Lun Huang 3 , Ho-Fai Wong 6 , Tsong-Hai Lee 3 , and Ho-Ling Liu 1,7
1
Department of Medical Imaging and
Radiological Sciences, Chang Gung University, Taoyuan,
Taiwan,
2
Department
of Biological Science and Technology, National Chiao
Tung University, Hsinchu, Taiwan,
3
Department
of Neurology and Stroke Center, Chang Gung Memorial
Hospital, and Chang Gung University College of Medicine,
Taoyuan, Taiwan,
4
Department
of Occupational Therapy, Chang Gung University, Taoyuan,
Taiwan,
5
Graduate
Institute of Biomedical Engineering, National Central
University, Taoyuan, Taiwan,
6
Department
of Medical Imaging and Intervention, Chang Gung Memorial
Hospital, Taoyuan, Taiwan,
7
Department
of Imaging Physics, The University of Texas M. D.
Anderson Cancer Center, Houston, TX, United States
Severe internal carotid artery (ICA) stenosis impairs
brain cognitive function, which might be originated from
cerebral hypoperfusion. However, the underlying brain
mechanisms remain largely unknown. This study aimed at
investigating the relationship of brain functional
connectivity and neuropsychology in both unilateral ICA
stenotic patients (N=27) and normal subjects (N=20). We
compared indicative network parameters between ICA
stenotic patients and normal subjects across two
hemispheres. We found lower degree and global efficiency
in the ipsilateral side to the stenosis. Moreover,
network parameters were positively correlated with
neuropsychological tests in the patients. Our results
implied that the patients with more deteriorated brain.
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