Abstract #3601

Measuring the time characteristic of the BOLD cerebrovascular reactivity response to a step hypercapnic stimulus.

Julien Poublanc ¹ , Adrian Crawley ¹ , Olivia Sobczyk ² , Gaspard Montandon ¹ , Kevin Sam ¹ , Daniel Mandell ¹ , Lakshmikumar Venkatraghavan ³ , James Duffin ³ , David Mikulis ¹ , and Joseph Fisher ³

¹ Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada, ² Institute of Medical Sciences, Ontario, Canada, ³ Department of Anaesthesia and Physiology, University Health Network, Toronto, Ontario, Canada

In this study, we investigated the dynamic aspect of the BOLD cerebrovascular reactivity response to a change in end-tidal PCO ₂ by developing a reliable method to measure its time characteristic, lower case Greek tau

. In healthy subjects, the mean lower case Greek tau

value in grey (GM) and white (WM) was respectively 20.210.5s and 40.710.7s. In patients, lower case Greek tau

is significantly prolonged ( lower case Greek tau

= 38.648.42s, p < 0.001) in GM with positive CO ₂ reactivity, ipsilateral to a stenosis. In the future, this method could be applied for investigating a variety of diseases that affect the cerebral vasculature or alter neurovascular coupling.

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