Abstract #3496
Neuroprotective effect of lactoferrin following inflammatory injury in the developing rat brain assessed by high-field neurite orientation dispersion and density imaging
Yohan van de Looij 1,2 , Vanessa Ginet 1 , Petra S Hppi 1 , and Stphane V Sizonenko 1
1
Division of Child Growth and Development,
University of Geneva, Geneva, Switzerland,
2
Laboratory
for Functional and Metabolic Imaging, Ecole
Polytechnique Fdrale de Lausanne, Lausanne,
Switzerland
Lactoferrin (Lf) is an iron-binding glycoprotein
secreted in milk known as antioxydant, anti-inflammatory
and antimicrobial. The aim of this work was to assess by
neurite orientation dispersion and density imaging the
neuroprotective effects of Lf during lactation on 3
days-old pup rats (corresponding to human preterm born
at 24-28 weeks of gestation) injected with
Lipopolysaccharide (LPS) in the corpus callosum. Results
show a neuroprotection of Lf supplemented in food during
lactation following LPS exposure with less altered
microstructure.
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