Abstract #3494
Brodmann revisited: Using diffusion MRI to characterize functionally distinct gray matter regions in development
Kirsten Mary Lynch 1 , Arthur Toga 1 , and Kristi Clark 1
1
Institute for Neuroimaging and Informatics,
University of Southern California, Los Angeles, CA,
United States
This study aims to elucidate in vivo correlations of
diffusion imaging parameters in order to yield
biologically relevant microstructural information. Here,
we use diffusion imaging parameters to (1) characterize
the underlying neuronal cytoarchitecture and columnar
organization of defined cortical regions and (2)
determine how these parameters change with age. We
relate regional variations in cortical thickness to mean
diffusivity and NODDI microstructural parameters
(orientation dispersion index and intra-neurite volume
fraction), to better characterize local microscopic
neural organization in vivo. Our results show that dMRI
measures are sensitive to the microstructural
differences between anatomically-defined regions of
functional significance throughout development.
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