Abstract #3445
Global structural network topology mediates neurocognitive outcome in children with congenital heart defects
Vincent Jerome Schmithorst 1 , Ashok Panigrahy 1 , Jessica Wisnowski 1 , Chris Walsh 2 , David Bellinger 2 , Jane Newburger 2 , and Michael Rivkin 2
1
Radiology, Children's Hospital of Pittsburgh
of UPMC, Pittsburgh, PA, United States,
2
Boston
Children's Hospital, Boston, MA, United States
The precise connection between brain
structural/functional differences and neurocognitive
deficits in patients with congenital heart defects (CHD)
remains poorly understood. We applied graph analysis to
DTI data acquired from adolescents born with
transposition of the great arteries (d-TGA) corrected
surgically in early infancy, and typically developing
controls. We used statistical mediation models to more
precisely delineate the relation between d-TGA,
perioperative factors, global structural network
topology, and neurocognitive outcomes. Differences in
network topology (increased modularity and
small-worldness, decreased global efficiency) mediated
worse neurocognitive outcome in d-TGA patients; these
effects were ameliorated by longer therapeutic
hypothermia during the arterial switch operation.
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