Abstract #3444
Decrease in functional network segregation in infants with congenital heart defects
Vincent Jerome Schmithorst 1 , Jodie Votava-Smith 2 , Vincent Lee 1 , Vidya Rajagopalan 2 , Shaheda Suleiman 2 , Lisa Paquette 2 , and Ashok Panigrahy 1
1
Radiology, Children's Hospital of Pittsburgh
of UPMC, Pittsburgh, PA, United States,
2
Children's
Hospital Los Angeles, Los Angeles, CA, United States
The effects of congenital heart defects (CHD) on early
brain development are not well understood. We used graph
analysis in order to better understand the impact of CHD
on functional network topology in infants. Compared to
healthy control neonates, CHD neonates displayed a
marked decrease in segregation metrics including
transitivity (p < 0.01) and modularity (p < 0.001); and
smaller clustering coefficient in multiple regions
mainly in the left hemisphere and greater participation
coefficient in multiple regions in both hemispheres. The
marked decrease in segregation in CHD neonates suggests
lower short-range functional connectivity and global
immature brain development.
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