Abstract #3433
Sphingosin-1-Phosphate-receptor modulation ameliorates neonatal white matter damage and improves long-term cognitive development
Yohan van de Looij 1,2 , Meray Serdar 3 , Petra S Hppi 1 , Ursula Felderhoff-Mser 3 , Ivo Bendix 3 , and Stphane V Sizonenko 1
1
Division of Child Growth and Development,
University of Geneva, Geneva, Switzerland,
2
Laboratory
for Functional and Metabolic Imaging, Ecole
Polytechnique Fdrale de Lausanne, Lausanne,
Switzerland,
3
Department
of Pediatrics, University Hospital Essen, Essen, Germany
Cerebral white matter injury is a leading cause of
adverse neuro-developmental outcome in prematurely born
infants. Experimental and clinical data from the adult
demyelinating disease multiple sclerosis revealed
immunomodulatory and cytoprotective effects of the
sphingosine-1-phosphate receptor modulating substance
Fingolimod (also known as FTY720). Therefore, the
neuroprotective role of FTY720 in a neonatal model of
oxygen-toxicity was investigated by using high-field
Diffusion Tensor Imaging (DTI), histology and protein
analysis. Results provide strong evidence for a
protective effect of FTY720 on oligodendrocyte in
hyperoxia-induced white matter damage coinciding with
microstructural ameliorations detected by DTI in later
life.
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