Abstract #3431
Quantitative analysis of global pattern of early cortical folding in polymicrogyria fetal brains
Kiho Im 1 , Alexandre Guimaraes 1 , Borjan Gagoski 1 , Caitlin Rollins 1 , Edward Yang 1 , and P. Ellen Grant 1
1
Boston Children's Hospital, Harvard Medical
School, Boston, MA, United States
This study aims to investigate global patterns of early
cortical folding and anatomically label primary sulci in
individual human fetal brains. We analyzed typically
developing and polymicrogyria (PMG) fetal brains by
measuring sulcal pattern similarity with normal fetal
brain templates. Our sulcal pattern comparison method
characterized interrelated sulcal arrangement and
patterning in the global cortical area, and effectively
detected abnormal global patterns of early primary sulci
in PMG in both hemispheres. Our method can help to
identify and quantify abnormal early cortical
organization even in the third trimester of fetal life
before cortical folding pattern is fully determined.
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