Abstract #3368
Sufficiency of Two-Pool Model for Quantitative Magnetization Transfer Imaging in Tumors
Ke Li 1,2 , Hua Li 1,3 , Xiao-Yong Zhang 1,2 , Ashley M Stokes 1,2 , Hakmook Kang 4 , Zhongliang Zu 1,2 , Chad C Quarles 1,2 , Daniel F Gochberg 1,2 , John C Gore 1,2 , and Junzhong Xu 1,2
1
Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States,
2
Department
of Radiology and Radiological Sciences, Vanderbilt
University, Nashville, TN, United States,
3
Department
of Physics and Astronomy, Vanderbilt University,
Nashville, TN, United States,
4
Department
of Biostatistics, Vanderbilt University, Nashville, TN,
United States
Quantitative Magnetization Transfer provides
measurements of macromolecular content in biological
tissues based on a two-pool model. This might be
oversimplified for biological tissues, such as tumor,
which consists of multiple water compartments. This work
demonstrated that with the presence of intermediate to
fast water exchange, the two-pool model is sufficient to
describe qMT data in tumors. Numerical simulations
validated this hypothesis. Further validations were
performed by injecting Gd-DTPA to selectively alter
extracellular relaxation properties in tumor bearing
animals. Across all dynamics, there were no significant
changes in the obtained pool size ratios.
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