Abstract #3352
Separated quantification of creatine and phosphocreatine based on a novel proton MR method combing 1 H-MRS and CEST MRI
Rong-Wen Tain 1,2 , Weiguo Li 3 , Shaolin Yang 4 , Xiaohong Joe Zhou 1,2 , and Kejia Cai 1,2
1
Radiology, College of Medicine, University
of Illinois at Chicago, Chicago, Illinois, United
States,
2
Center
for MR Research, College of Medicine, University of
Illinois at Chicago, Chicago, Illinois, United States,
3
Research
Resource Center, University of Illinois at Chicago,
Illinois, United States,
4
Psychiatry,
College of Medicine, University of Illinois at Chicago,
Chicago, Illinois, United States
The conversion of phosphocreatine (PCr) to creatine (Cr)
by the creatine kinase produces ATP. However, 1H-MRS
measures the total creatine due to the overlapping of
PCr and Cr in 1H-MRS. Other techniques such 31P-MRS is
limited by low sensitivity and resolution. The goal of
this preliminary study is to prove the concept that PCr
and Cr can be individually quantified using a combined
proton MR method based on CEST MRI and 1H-MRS. Various
PCr and Cr concentration phantoms were scanned using
CEST MRI and 1H-MRS. Results demonstrated that PCr and
Cr concentration can be individually quantified by using
the proposed method.
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