Abstract #3247
B1 and B0 Sensitivity of Spin-Lock Preparation Pulses for Whole-Brain Quantitative T1rho Mapping
Casey P. Johnson 1 and Vincent A. Magnotta 1
1
Radiology, University of Iowa, Iowa City,
IA, United States
T1ρ mapping has found application for a variety of brain
diseases. However, to accurately quantify T1ρ in the
brain, particularly in difficult regions near air-tissue
interfaces such as portions the frontal lobe, new
spin-lock prep pulses are needed. This work simulates
the T1ρ quantification accuracy of a number of spin-lock
prep pulses, including those with adiabatic excitation
and refocusing pulses, over an expected range of B1 and
B0 field inhomogeneities calculated from 24 in vivo
whole-brain scans. It is shown that use of adiabatic
excitation pulses improves T1ρ accuracy in regions of
the brain susceptible to B1 and B0 offsets.
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