Abstract #3246
Monte Carol modeling of the non-monoexponential CPMG relaxation in iron overload
Chu-Yu Lee 1,2 and Jens H Jensen 1,2
1
Department of Radiology and Radiology
Science, Medical University of South Carolina,
Charleston, SC, United States,
2
Center
for Biomedical Imaging, Medical University of South
Carolina, Charleston, SC, United States
In patients with iron overload, the CPMG measurement in
liver exhibits a non-monoexponential decay. By using a
theoretical model, one can decompose the decay into two
major components associated with the two forms of
endogenous tissue iron: ferritin and hemosiderin. A
separate quantification may be useful in assessing iron
storage and chelation therapy, because ferritin iron may
more directly reflect iron toxicity. However, the
validity of the quantitative model has not been
previously studied with numerical simulations of in vivo
iron deposits with heterogeneous sizes and spatial
distributions. In this work, we investigate the models
performance in realistic tissue geometry by simulating
the MR relaxation from iron spheres with statistically
distributed sphere sizes. The simulated iron
concentrations of ferritin and hemosiderin were varied
over a clinically relevant range. As a reference,
conventional bi-exponential fits to the signals were
also calculated.
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