Abstract #2953
A novel method to estimate labeling efficiency for pseudo-continuous arterial spin labeling imaging
Zhensen Chen 1,2 , Xingxing Zhang 2 , Andrew G. Webb 2 , Xihai Zhao 1 , and Matthias J.P. van Osch 2
1
Center for Biomedical Imaging Research,
Department of Biomedical Engineering, School of
Medicine, Tsinghua University, Beijing, China,
2
C.J.
Gorter Center for High Field MRI, Department of
Radiology, Leiden University Medical Center, Leiden,
Zuid-holland, Netherlands
A novel method based on multi-phase pseudo-continuous
ASL (pCASL) imaging distal to the labeling plane was
proposed to estimate labeling efficiency. The acquired
in vivo ASL signals were consistent with the expected
curves from simulations of pCASL imaging using laminar
flow model. The labeling efficiencies calculated from in
vivo data were in line with theoretical simulation in
spite of some measurement errors that might be due to
cardiac pulsation and partial volume effect. The method
is fast, promising and requires more investigation for
improvement of robustness and quantification.
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