Abstract #2952
Measuring the influence of vessel geometry on pCASL labeling efficiency
Jan Petr 1 , Georg Schramm 1 , and Jrg van den Hoff 1
1
Institute of Radiopharmaceutical Cancer
Research, Helmholtz-zentrum Dresden Rossendorf, Dresden,
Germany
Influence of vessel angulation and presence of vessel
bends in the labeling plane on the resulting CBF was
studied for a pseudo-continuous ASL through numerical
simulations. Experimental comparison by repositioning
and angulation of the labeling plane was done in five
healthy volunteers. CBF change of less than 5% for plane
angulations of up to 30 was expected from simulations
and confirmed by experiments. Up to 30% difference in
labeling efficiency was expected on tortuous vessels and
8.4% and 16.9% decrease in CBF was observed in the
posterior cerebral artery and vertebral artery vascular
territories.
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