Abstract #2867
Comparison of seven compartment models of diffusion in prostate tissue
Sisi Liang 1 , Eleftheria Panagiotaki 2 , Peng Shi 1 , and Roger Bourne 3
1
College of Engineering and Science, Victoria
University, Melbourne, Vic, Australia,
2
Centre
for Medical Image Computing, University College London,
London, England, United Kingdom,
3
Discipline
of Medical Radiation Sciences, Faculty of Health
Sciences, University of Sydney, Sydney, NSW, Australia
Structure-based modelling of DWI in tissue is becoming a
powerful tool for probing microstructure and pathology.
A recent study demonstrated the feasibility of a
three-component structure-based model called VERDICT for
imaging prostate cancer in vivo with DWI at clinical
setting with high sensitivity and specificity. Motivated
by this new finding, this work investigated the
non-perfusion components of the VERDICT model in
prostate tissue ex vivo at 9.4 T. Seven compartment
models with up to 3 components were compared using
Akaikes information criterion. The best-performed
model had two compartments with one anisotropic and one
restricted compartment.
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