Abstract #2866
Double-Pulsed Gradient Spin-Echo from DTI in the Fibromuscular Stroma of the Prostate
Scott A. Willis 1 , Timothy Stait-Gardner 1 , William S. Price 1 , and Roger Bourne 2
1
Nanoscale Organisation and Dynamics Group,
School of Science and Health, University of Western
Sydney, Sydney, NSW, Australia,
2
Discipline
of Medical Radiation Sciences, Faculty of Health
Sciences, University of Sydney, Sydney, NSW, Australia
Self-diffusion reports on binding events, restrictions
and anisotropies of the system from porous rock to
biological tissue, and can be measured using pulsed
gradient spin-echo (PGSE) NMR. Double-pulsed gradient
spin-echo (DPGSE) is useful for probing molecular
dynamics as well as pore sizes and orientation, giving
more information than single PGSE measurements. This
work investigates angular DPGSE profiles (i.e.,
equivalent gradient strengths for each PGSE block of the
DPGSE but with varying angular separation) in prostate
tissue and the use of DTI results to simulate the DPGSE
profile for a one-voxel DPGSE measurement.
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