Abstract #2762
Quantitative Quality Assurance Metrics in a High Angular Resolution Diffusion Imaging (HARDI) Multicenter Study
Xiaopeng Zhou 1 , Ken Sakaie 1 , Josef Debbins 2 , Robert Fox 1 , and Mark Lowe 1
1
The Cleveland Clinic, Cleveland, OH, United
States,
2
Barrow
Neurological Institute, Phoenix, AZ, United States
In a multicenter trial, QA metrics are necessary to
provide confidence in data quality and indicate when
scanner repairs may be necessary. Quantitative
assessment may provide the ability to detect subtle
degradation in scanner performance, offering an
opportunity to repair the scanner proactively. An
important result would be to avoid costly repeat scans
or lost data in a multicenter trial. We propose a
receiver operating characteristic (ROC) analysis to
establish quantitative thresholds on SNR. We demonstrate
the use of this method on phantom data acquired from 27
sites in the SPRINT-MS, a phase II trial of treatment
for progressive multiple sclerosis.
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