Abstract #2757
Theoretical study of the free water elimination model
Quinten Collier 1 , Jelle Veraart 1,2 , Ben Jeurissen 1 , Arnold J. den dekker 1,3 , and Jan Sijbers 1
1
iMinds-Vision Lab, University of Antwerp,
Antwerp, Antwerp, Belgium,
2
Center
for Biomedical Imaging, New York University Langone
Medical Center, New York, New York, United States,
3
Delft
Center for System and Control, Delft University of
Technology, Delft, Netherlands
Partial volume effects caused by cerebrospinal fluid are
an important issue in diffusion MRI. In this work, we
study the free water elimination model by analyzing the
Cramr-Rao lower bound (CRLB) of its parameters. We show
that through optimizing the acquisition protocol by
minimizing the trace of the CRLB, a significant gain in
the precision of the parameter estimation can be
achieved. Moreover, further analysis indicates that
regularization and/or constraints are necessary for
parameter estimation from voxels with large CSF
fractions and/or low FA values. These theoretical
findings are confirmed by both simulation and real data
experiments.
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