Abstract #2733
Fast Quantification of Global Cerebral Metabolic Rate of Oxygen (CMRO 2 )
Suliman Barhoum 1 , Michael C. Langham 1 , Jeremy F. Magland 1 , Chamith S. Rajapakse 1 , Cheng Li 1 , and Felix W. Wehrli 1
1
Radiology, University of Pennsylvania,
Philadelphia, Pennsylvania, United States
The cerebral metabolic rate of oxygen consumption (CMRO
2
)
is an important, tightly regulated, physiologic
parameter. A recently reported quantitative MRI method
denoted OxFlow has been shown to be able to quantify
whole-brain CMRO
2
by
simultaneously measuring oxygen saturation (SvO
2
)
and cerebral blood flow (CBF) in the major vessels
draining and feeding the brain in 30 seconds, which is
typically adequate for measurement at baseline but not
necessarily in response to neuronal activation. Here, we
present an improved version of the pulse sequence that
quantifies CMRO
2
in
10 seconds scan time and compared it with the parent
sequence in eight subjects. Results indicate good
agreement between both sequences, with mean differences
of 2%, 3%, and 1% for SvO
2
, CBF, and CMRO
2
,
respectively.
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