Abstract #2610
MONITORING THE RESORPTION OF MYOCARDIAL INFARCT IN THE PRESENCE AND ABSENCE OF CORONARY MICROEMBOLI USING MRI AND MICROSCOPY
Maythem Saeed 1 , Loi Do 1 , Roland Krug 1 , Steven W Hetts 1 , and Mark W Wilson 1
1
Radiology and Biomedical Imaging, University
of California San Francisco, San Francisco, Ca, United
States
The aim of this swine study was to longitudinally
quantify microemboli effects on viability of previously
ischemic myocardium using MRI (at 3 days and 5 weeks
after intervention) and microscopy (5 weeks). Animals
were subjected to 45min LAD coronary artery occlusion
with and without microemboli. Delayed contrast enhanced
MRI has the potential to detect additional loss of
cellular integrity in ischemic myocardium exposed to
microembolization, but with limited spatial resolution
for quantifying true microinfarct compared to
microscopy. Cardiac injury biomarkers suffer similar
limitation. MRI may be useful in testing the efficacy of
newer techniques designed to minimize microemboli during
revascularization.
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