Abstract #2330
Improving Look & Locker readout for pCASL using a variable Flip Angle sweep
Marco Castellaro 1 , Alessandra Bertoldo 1 , Denis Peruzzo 2 , Filippo Arrigoni 2 , and Matthias Van Osch 3
1
Department of Information Engineering,
University of Padova, Padova, Italy,
2
Department
of Neuroimaging, Research institute IRCCS "E. Medea",
Bosisio Parini, Lecco, Italy,
3
C.J. Gorter
Center for High Field MRI, Radiology, Leiden University
Medical Center, Leiden, Netherlands
Arterial spin labelling (ASL) is a technique that
permits to estimate perfusion non-invasively. The
readout phase of ASL sequence can follow several
schemes. In particular, to sample the entire kinetic
curve of the inflowing blood the use of a Look&Locker
(LL) read-out has been proposed. The LL approach
suffers, however, from a progressively lower
Signal-to-Noise Ratio (SNR) for later post-labeling
delays (PLDs) due to T1-relaxation and the fact that the
label experienced multiple excitation pulses. This work
presents an approach to optimize the SNR over all PLDs
of a LL read-out scheme by introducing a variable
flip-angle (FA) sweep.
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