Abstract #2327
A Simplified Spin and Gradient Echo (SAGE) Approach for Brain Tumor Perfusion Imaging
Ashley M Stokes 1 and C. Chad Quarles 1
1
Institute of Imaging Science, Radiology and
Radiological Sciences, Vanderbilt University, Nashville,
TN, United States
Contrast agent leakage in tumors can severely reduce the
reliability of DSC perfusion measures due to competing T
1
effects.
While dual gradient-echo (GE) sequences can provide
robust T
1
-insensitive GE hemodynamic
measures, no analogous method exists for T
1
-insensitive
spin-echo (SE) measures. Here, we propose a simplified
spin- and gradient-echo (sSAGE) approach that utilizes a
combined dual GE and SE sequence and an analytical
solution for T
1
-insensitive ∆R
2
*
and
∆R
2
timecourses.
As this approach only requires acquisition and storage
of three echoes and does not rely upon computationally
demanding non-linear fitting, it could facilitate more
rapid clinical translation and adoption of SAGE-based
DSC-MRI.
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