Abstract #2326
On the Use of DSC-MRI for Measuring Vascular Permeability
Jack T Skinner 1,2 , Paul L Moots 3 , and C Chad Quarles 1,2
1
Radiology and Radiological Sciences,
Vanderbilt University Medical Center, Nashville, TN,
United States,
2
Institute
of Imaging Science, Vanderbilt University Medical
Center, Nashville, TN, United States,
3
Neurology,
Vanderbilt University Medical Center, Nashville, TN,
United States
Leakage of contrast agent can confound DSC-MRI
measurements, necessitating correction techniques.
Parameters relating to contrast extravasation (
K
2
,
K
a
)
can be extracted from these techniques. Dual
gradient-echo acquisitions also mitigate leakage effects
and allow the extraction of T
1
-weighted data
and subsequently the computation of DCE-MRI parameters
K
trans
and
v
e
.
Using dual-echo DSC-MRI, these parameters were
simultaneously compared. A poor voxel-wise correlation
was found between
K
2
and
K
a
and
K
trans
,
potentially attributed to competing T
1
and
T
2
* leakage effects and echo time dependence.
A strong correlation was observed, however, between
K
2
and
K
a
and
v
e
,
suggesting a relationship with the extravasation space.
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