Abstract #2201
The abnormality of functional connectivity in Parkinsons in dopaminergic regions
Yue Xing 1 , Stefan Schwarz 1 , Nin Bajaj 2 , Penny Gowland 3 , and Dorothee Auer 1
1
Sir Peter Mansfield Imaging Centre, School
of Medicine, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom,
2
Division
of Neurology, Nottingham University Hospitals NHS Trust,
Nottingham, Nottinghamshire, United Kingdom,
3
Sir
Peter Mansfield Imaging Centre, School of Physics and
Astronomy, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom
Differential functional connectivity patterns of
anterior substantial nigra and posterior substantial
nigra in Parkinsons were identified by comparing with
age- and sex-matched healthy volunteers with seed-based
analysis on cross-scanner resting state fMRI data. This
abnormal functional connectivity reduction of the
anterior and posterior substantial nigra in Parkinsons
may suggest a link between posterior default-mode
network impairment and dopaminergic deficit.
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