Abstract #2199
Application of GluCEST MRI in Detection of Epileptogenic Foci in Temporal Lobe Epilepsy
Ravi Prakash Reddy Nanga 1 , Kathryn A. Davis 2 , Sandhitsu Das 3 , Stephanie H. Chen 2 , Peter Hadar 2 , Timothy H. Lucas 4 , Brian Litt 2 , John A. Detre 2 , Hari Hariharan 1 , Mark A. Elliott 1 , and Ravinder Reddy 1
1
Radiology, University of Pennsylvania Health
Systems, Philadelphia, Pennsylvania, United States,
2
Neurology,
University of Pennsylvania, Philadelphia, Pennsylvania,
United States,
3
Penn
Image Computing & Science Lab, University of
Pennsylvania, Philadelphia, Pennsylvania, United States,
4
Neurosurgery,
University of Pennsylvania, Philadelphia, Pennsylvania,
United States
Glutamate is widely thought to be central to
epileptogenesis. Here we apply a novel noninvasive
glutamate imaging technique, GluCEST (Glutamate Chemical
Exchange Saturation Transfer) MRI at 7T with an aim to
identify seizure foci with finer precision and higher
sensitivity than currently used imaging modalities in
subjects with Temporal Lobe Epilepsy (TLE).
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