Abstract #2156
Cerebrovascular damage after stroke in type two diabetic rats measured by MRI
Guangliang Ding 1 , Tao Yan 1 , Jieli Chen 1 , Michael Chopp 1,2 , Lian Li 1 , Qingjiang Li 1 , Chengcheng Cui 1 , Ruizhuo Ning 1 , and Quan Jiang 1
1
Neurology, Henry Ford Hospital, Detroit,
Michigan, United States,
2
Physics,
Oakland University, Rochester, Michigan, United States
Using a suture 2h occlusion and reperfusion stroke model
and a low dose Streptozotocin injection combined with a
high fat food diet diabetic model of young adult Wistar
rats, Gd-DTPA leakage measured by CE-T1WI indicates that
T2DM rats suffered more severe BBB disruption from 1 to
5 weeks after stroke (p<0.005), and SWI identified
significant larger hemorrhagic volumes in T2DM rats
throughout 5w after stroke (p<0.05), compared with WT
rats. FA values of ischemic boundary in the striatum
were consistently lower in the T2DM rats than in the WT
controls, which suggest that T2DM hampers axonal density
increase.
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