Abstract #2155
Age Dependent Differences in Photothrombotic Ischemic Injury Detected Using Quantitative MR Imaging
Ursula Tuor 1 , Min Qiao 2 , Manasi Sule 2 , Qinbo Deng 2 , Melissa Morgunov 2 , David Rushforth 2 , and Tadeusz Foniok 2
1
Physiology and Pharmacology, Cl
Neurosciences and Radiology, University of Calgary,
Calgary, AB, Canada,
2
University
of Calgary, Calgary, AB, Canada
We investigated whether differing severities of
photothrombotic insults could be produced in immature
brain as observed in adult rats previously. Mild lesions
in neonatal cortex consisted of small hyperintense DW
regions corresponding to marked increases in T2. In
contrast, adults had hyperintense DW regions
corresponding to marked T2 increases but also modest T2
increases beyond the DW lesion border. In contrast to
neonatal brain, T2 is more sensitive for detecting
ischemic injury than DW in adult brain. The results
indicate a promising approach to study thrombotic
occlusion and reperfusion injury and its MR diagnosis
using quantitative T2, DW and ADC.
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