Abstract #2129
Test-retest reproducibility of the BOLD response to a hypercapnic challenge
Bryon A. Mueller 1 , Nicholas Evanoff 2 , Kara L. Marlatt 2 , Justin R. Geijer 3 , Kelvin O. Lim 1 , and Donald R. Dengel 2
1
Department of Psychiatry, University of
Minnesota, Minneapolis, MN, United States,
2
School
of Kinesiology, University of Minnesota, Minneapolis,
MN, United States,
3
Department of Health,
Exercise and Rehabilitative Sciences, Winona State
University, Winona, MN, United States
BOLD imaging during a hypercapnic challenge is often
used to measure cerebral vascular reactivity.
Determining the within and between day reproducibility
of the BOLD signal change in response to a reproducible
hypercapnic challenge will help determine if this method
is precise enough to be used as a research tool to
compare specific groups to control populations. We have
measured the intraclass correlation coefficient and
coefficient of within-subject variation for BOLD imaging
during an iso-oxic, hypercapnic square stimulus. Results
show excellent within day reproducibility and good
between day reproducibility within the cerebral gray
matter.
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