Abstract #2128
Physiological Modulators of Resting-State MRI Functional Connectivity
Powell Pui Wai Chu 1,2 , Ali M. Golestani 1 , Jonathan B. Kwinta 1,2 , Yasha B. Khatamian 1 , and Jean J. Chen 1,2
1
Rotman Research Institute, Baycrest,
Toronto, Ontario, Canada,
2
Medical
Biophysics, University of Toronto, Toronto, Ontario,
Canada
Resting-state fMRI functional connectivity (rs-fcMRI)
measurements are based on the BOLD fMRI signal, which is
influenced by systemic physiological variability. Thus,
fcMRI data interpretation may be difficult across
different subjects without the knowledge of these
physiological influences. In this work, in order to
improve the reliability of rs-fcMRI measurements, we
assess the influence of physiological factors including
baseline cerebral blood flow and venous blood
oxygenation on functional connectivity estimates. We
found a significance relationship between rs-fcMRI
values and the above two physiological variables.
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