Local intrinsic connectivity measures relate to GABA/Glx levels

In presented study, a combined fMRI-MRS study has been performed to examine interactions between GABA/Glx levels and local intrinsic brain activity (iFC). Recently there has been considerable progress done in investigating interactions between GABA level and BOLD signal change during visual stimulation. What has not been carefully studied yet is the relationship between resting state coherent BOLD signal change (functional connectivity) and excitatory/inhibitory neurotransmitter balance. Therefore, GABA and Glx concentration in the occipital cortex were correlated with local functional connectivity (lFC) and amplitude of low frequency fluctuations (ALFF) of the resting brain in eyes-open and eyes-closed condition.

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