Abstract #2026
Changes in resting state networks and biochemistry in a mouse model of inflammatory pain
Robert Becker 1 , Anke Tappe-Theodor 2 , Ainhoa Bilbao 3 , Rainer Spanagel 3 , and Wolfgang Weber-Fahr 1
1
Research group Translational Imaging,
Department of Neuroimaging, Central Institute of Mental
Health, Medical Faculty Mannheim / Heidelberg
University, Mannheim, BW, Germany,
2
Pharmacological
institute, Heidelberg University, Heidelberg, BW,
Germany,
3
Department
of Psychopharmacology, Central Institute of Mental
Health, Medical Faculty Mannheim / Heidelberg
University, Mannheim, BW, Germany
In a pilot rsfMRI/MRS study we investigated the effects
of inflammatory pain on brain network structure in a
group of 16 mice. Pain was induced by injection of
Complete Freund's adjuvant (CFA). We found significant
differences in local network parameters of 10 regions,
mostly related with mood/stress/reward systems. The
changes of local network features in these regions show
their more global and less local role in the network.
Furthermore quantified MR-Spectra show a trend for
increased glutamate and glutamine concentrations in the
prefrontal cortex of the CFA-group, which supports our
working hypothesis of a hyper-glutamatergic input to the
nucleus acumbens.
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