Abstract #1981
In Vivo Longitudinal Measurements Of Brain Energy Metabolism in Chronic Hepatic Encephalopathy in a Rat Model using 31P MRS and 1H MRS
Veronika Rackayova 1 , Bernard Lanz 1 , Corina Berset 2 , Rolf Gruetter 1,2 , Valrie A. McLin 3 , Olivier Braissant 4 , and Cristina Cudalbu 2
1
Laboratory of Functional and Metabolic
Imaging, Center for Biomedical Imaging, Ecole
Polytechnique Fdrale de Lausanne (EPFL), Lausanne,
Vaud, Switzerland,
2
Centre
d'Imagerie Biomedicale (CIBM), Ecole Polytechnique
Fdrale de Lausanne (EPFL), Lausanne, Vaud,
Switzerland,
3
Swiss
Center for Liver Disease in Children, Department of
Pediatrics, University Hospitals Geneva, Geneva,
Switzerland,
4
Service
of Biomedicine, University Hospital of Lausanne,
Lausanne, Vaud, Switzerland
1H MRS and 31P MRS were used to study brain (energy)
metabolism in Hepatic Encephalopathy (HE) in animal
model of Chronic liver disease. We could see 2-fold
increase of Gln and decrease in other brain osmolytes
but only non-significant decrease in ATP suggesting that
mild brain edema, present in HE, is unlikely due to
energy disturbances but rather high concentrations of
the osmotically active Gln look, for the moment, as one
of the principal causes.
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