Abstract #1980
High glutamine C57BL/6 mice
Ivan Tkac 1
1
Center for Magnetic Resonance Research,
University of Minnesota, Minneapolis, MN, United States
C57BL/6 is the most widely used mouse strain used in
different research areas including developmental biology
and neuroscience. In addition, C57BL/6 mice are commonly
used as a background strain in the production of
transgenic mouse model of human neurodegenerative
diseases. But these mice exhibit a sporadic congenital
portosystemic shunt resulting in abnormally high levels
of brain glutamine. This study we demonstrate how
1
H
MRS can help to identify these mice to eliminate
potential bias in studies using this mouse strain.
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