Abstract #1915
Adult Neurogenesis and Olfactory Activity Regulate Olfactory Bulb Volume
Nikorn Pothayee 1 , Diana Cummings 2 , Timothy Schoenfeld 3 , Heather Cameron 3 , Leonardo Belluscio 2 , and Alan Koretsky 1
1
Laboratory of functional and molecular
imaging, NINDS, NIH, Bethesda, MD, United States,
2
Developmental
neural plasticity section, NINDS, NIH, Bethesda, MD,
United States,
3
Neuroplasticity Section, NIMH,
NIH, Bethesda, MD, United States
Olfactory bulb displays remarkable plasticity and its
volume changes have been implicated in many CNS
pathologies such as Alzheimers and Parkinsons
diseases. Understanding factors that play role in
regulating the OB and its size may yield insights into
the OB plasticity. In this work, we utilize longitudinal
cellular MRI in combination with transgenic animal model
of adult neurogenesis to study interplaying effects of
olfactory input level and neurogenesis on the dynamic
volume changes of the olfactory bulb.
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