Abstract #1887
Quantitative analysis for hyperpolarized 13 C-pyruvate imaging: comparison of methods on a clinical system.
Charlie J Daniels 1 , Mary A McLean 2 , Nicholas McGlashan 1 , Martin J Graves 1 , Fraser J Robb 3 , David J Lomas 1 , Rolf F Schulte 4 , Kevin M Brindle 2 , and Ferdia A Gallagher 1,2
1
Department of Radiology, University of
Cambridge, Cambridge, United Kingdom,
2
Cancer
Research UK Cambridge Institute, University of
Cambridge, Cambridge, United Kingdom,
3
USA
Instruments Inc., Aurora, Ohio, United States,
4
GE
Global Research, Munich, Germany
Hyperpolarized imaging with
13
C-labelled
endogenous molecules is on the verge of clinical
translation. A simple, robust and objective method of
quantitative analysis is required to process
hyperpolarized data clinically, however there is
currently debate over the best methods to apply. We
assessed four quantitative methods by imaging conversion
of [1-
13
C]pyruvate to [1-
13
C]lactate
using a clinical polarizer system at 3 T and a pyruvate
concentration predicted for future patient studies. We
conclude that extracting data from a single voxel is
sufficiently robust and suggest the area under the curve
ratio be taken forward as a standardised clinical
parameter.
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